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#nuclear export

2 public questions tagged with this topic.

Protein Sorting and Trafficking

The export of proteins from the nucleus requires:

Export of proteins from the nucleus depends on recognition of leucine-rich nuclear export signals that provide dominant cue for exit to the cytoplasm. Canonical NES consists of short amphipathic alpha-helix with regularly spaced large hydrophobic residues, typically leucine, isoleucine, valine or phenylalanine, arranged in pattern Φ-X2-3-Φ-X2-3-Φ-X-Φ where Φ denotes hydrophobic. This motif docks into hydrophobic groove formed by HEAT repeats 11 and 12 of chromosome region maintenance 1, CRM1, also called Exportin-1 or XPO1, stabilized only when Ran is in GTP-bound state present at high concent

Ref: Lodish et al., Molecular Cell Biology, 9th ed., Chapter 13: CRM1 Exportin Recognition of Leucine-Rich NES.

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Cell Signaling ELR Pathways - I

Smad nuclear export and reset requires

exportins and phosphatases, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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