Practice question

Unipotent stem cells self-renew and produce only single differentiated lineage, unlike multipotent or pluripotent counterparts generating multiple fates. Spermatogonial stem cells residing on basement membrane of seminiferous tubules supported by Sertoli cell niche via GDNF and FGF2 divide to maintain themselves and produce differentiating spermatogonia that undergo meiosis forming spermatozoa exclusively, ensuring lifelong spermatogenesis. Hematopoietic stem cells multipotent generating myeloid and lymphoid lineages, mesenchymal stem multipotent forming bone fat cartilage, neural crest stem multipotent forming neurons glia melanocytes. Spermatogonial unipotency reflects commitment to spermatogenesis ensuring continuous gamete production throughout male reproductive lifespan and fertility.