Practice question
Question
Which of the following describes the fate of P3.p, P4.p, and P8.p in normal development?
Explanation
Vulval precursor equivalence group spans P3.p-P8.p in ventral hypodermis, maintained by LIN-39 Hox preventing hypodermal fusion during larval stages. In wild type, only P5.p-P7.p receive sufficient LIN-3 EGF from anchor cell during L3 stage to induce vulval fates via Ras-MAPK and BAR-1 Wnt competence. P3.p, P4.p, P8.p receive below-threshold LIN-3 due to distance and are uninduced, adopting tertiary 3° fate, fusing with hyp7 syncytium via EFF-1 fusogen without dividing, becoming part of large hypodermal syncytium, not contributing to vulva, representing default epidermal fate when RTK absent.
Discussion
Comments
Please log in to join the discussion.
Login to commentNo comments yet. Be the first to start the discussion.