Practice question
Question
Vitamin B12 deficiency can be diagnosed by urinary excretion of:
Explanation
Vitamin B12 is cofactor for methylmalonyl-CoA mutase converting L-methylmalonyl-CoA to succinyl-CoA. Deficiency blocks this reaction causing accumulation of methylmalonic acid excreted in urine. Measurement of urinary methylmalonate thus serves as sensitive functional diagnostic marker for cobalamin deficiency distinguishing from folate deficiency.
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