Practice question
Question
The mouse homozygous null mutant for a gene bfg always dies mid-gestation. Chimeric mice made of bfg null cells and wild-type cells have healthy pups. When the developing brain of these pups is examined, they have more than two hippocampi. Closer examination reveals bfg null cells at the centre of these supernumerary hippocampi. Which of the following inferences can correctly be drawn from this experiment?
Explanation
In the mouse homozygous null mutant for a, Wild type bfg function in the developing brain suppresses hi represents established outcome. functional assays confirms option B (Wild type bfg function in the ) as correct, while alternatives misstate substrate or regulatory direction, contradicting textbook data.
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