Practice question

Acronym SRY coined after positional cloning of testis-determining factor on Y chromosome through deletion mapping in XY females and translocation in XX males. It stands for Sex-determining Region of Y chromosome, located on short arm Yp encompassing single exon encoding highly conserved HMG box DNA-binding domain essential for bending DNA and triggering Sox9 expression. Terminology distinguishes master switch from larger Y functions including azoospermia factor regions. Understanding acronym clarifies localization and function as genetic determinant present in minimal Y fragment sufficient to induce male development when translocated.