Practice question

Src-homology 2 (SH2) domains are modular protein modules that recognize phosphotyrosine residues in a sequence-specific context. Binding of an SH2 domain to a phosphorylated tyrosine creates a high-affinity docking site that recruits downstream signaling proteins to activated receptor tyrosine kinases or adaptor complexes. This interaction is a central mechanism of phosphotyrosine-dependent signal propagation.