Practice question

In Xenopus unfertilized egg Dishevelled protein associated with vesicles anchors to vegetal cortex via interaction with VegT-localizing machinery and kinesin motors. Vegetal pole cortex also holds Vg1 and Wnt11 mRNAs. Upon sperm entry, parallel microtubule array assembles and transports Dishevelled vesicles dorsally toward future dorsal side, 30 degrees opposite sperm entry. At dorsal vegetal cortex Dishevelled inhibits Axin-GSK3 complex stabilizing beta-catenin. Animal pole cortex initially depleted of Dishevelled, explaining dorsal determinant transport from vegetal pole to dorsal equator necessary for Gray crescent and Nieuwkoop center establishment.