Practice question

cAMP receptors cAR1 through cAR4 are classical seven-transmembrane heterotrimeric G protein-coupled receptors with high homology to mammalian chemoattractant receptors. They couple to G alpha 2 and G beta-gamma complexes activating multiple effectors including adenylyl cyclase, phospholipase C, PI3K, and MAPK, coordinating chemotaxis and gene expression. They are not ligand-gated ion channels, receptor tyrosine kinases that autophosphorylate, or nuclear hormone receptors residing intracellularly. cAR1 possesses highest affinity, rapidly desensitizes, and establishes oscillatory dynamics essential for wave propagation. Gene disruption of cAR1 abolishes aggregation and chemotactic streaming during starvation.