Practice question

MCQ

Question

An E.coli mutant defective for an enzyme is unable to grow on acetate but grows on glycerol as the sole carbon source. Which ONE of the following enzymes is likely to be defective in this mutant?

Options

Choose one · Correct answer highlighted

Isocitrate dehydrogenase Glyceraldehyde 3-phospahte dehydrogenase Pyruvate dehydrogenase Isocitrate lyase Correct

Explanation

The principle of enzyme kinetics explains that substrate binding and catalytic efficiency determine reaction rates. Hence Isocitrate lyase fits best because it reflects active-site specificity and regulation, as documented in authoritative sources on biochemistry.

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