Practice question

Anti-Müllerian hormone is dimeric glycoprotein of TGF-beta family secreted by Sertoli cells of fetal testis under SOX9 activation soon after SRY determination. AMH binds AMHR2 receptors on mesenchyme surrounding Müllerian ducts, triggering apoptosis and extracellular matrix remodeling causing duct regression in male embryos between weeks 8-10. This prevents development of uterus, fallopian tubes and upper vagina, allowing Wolffian duct differentiation toward male tract under testosterone. In females absence of AMH permits Müllerian duct persistence forming female reproductive tract. Mutations cause persistent Müllerian duct syndrome. AMH does not induce spermatogenesis or Leydig differentiation directly.