Practice question

Anti-Müllerian Hormone performs male-specific function of eliminating female reproductive duct anlage. Secreted shortly after testis cords form by Sertoli cells, AMH binds Amhr2 receptor serine-threonine kinase on mesenchyme of Müllerian ducts leading to phosphorylation of Smad1/5/8, induction of matrix metalloproteinases, inhibition of Wnt7a and apoptosis of duct epithelium. Resulting regression prevents formation of uterus, oviducts and upper vagina in males ensuring only Wolffian derivatives develop. Mutations in AMH or receptor cause Persistent Müllerian Duct Syndrome where males retain uterus alongside normal testes.