Practice question

Acrosome is Golgi-derived cap-shaped secretory vesicle forming anterior to spermatid nucleus during spermiogenesis. Golgi stacks contribute proacrosomal granules that coalesce into single granule attaching to nuclear envelope, expanding over half nuclear surface. Containing hyaluronidase acrosin and acid hydrolases similar to lysosomal enzymes, organelle functionally analogous to lysosome but specialized for fertilization. Acrosome formation requires Hrb, GOPC and pick1 genes; defects cause globozoospermia with round heads lacking acrosome resulting in infertility due to inability to penetrate zona pellucida, access oolemma, trigger fusion and activate oocyte for development.