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Question

A 5250 base-pair long plasmid with 10 negative supercoils would have a linking number of ____________, considering 10.5 base pairs per turn for B DNA. (Answer in integer) (NAT)

Explanation

The principle of DNA replication fidelity explains that polymerase proofreading and origin firing ensure accurate duplication. Hence Option NAT fits best because it matches high-fidelity synthesis mechanisms, as documented in authoritative sources on molecular biology.

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