What is the genetic cause of sickle-ll anemia?
Sickle-ll anemia is caused by a single base substitution in the β-globin gene, leading to the replacement of glutamic acid with valine. This follows from NCERT principle where the relation explains the outcome clearly for students in simple steps.
Ref: NCERT Biology Textbook for Class XI and XII (Botany section), Chapter: Cell Structure and Function, Cell Cycle and Biomolecules, Topic: Cell organelles and biomolecular structure.