Ph1 gene in wheat ensures:
Pairing homoeologous1, Ph1 locus on long arm of chromosome 5B in hexaploid wheat Triticum aestivum encodes ZIP4-B2 protein that suppresses homoeologous chromosome pairing between related A, B, and D subgenomes, enforcing strictly homologous bivalent pairing during meiosis. Without Ph1, homoeologs from different subgenomes would synapse forming multivalents and translocations, causing sterility and aneuploidy, as seen in ph1 mutants where extensive homoeologous pairing occurs and multivalents observed cytologically. Ph1 promotes homolog recognition via telomere bouquet organization and restrict
Ref: Riley R & Chapman V 1958 Nature – Ph1 homologous pairing discovery; Griffiths et al. 2006 Nature cloning of Ph1