When comparing multiple genomes, syntenic blocks are identified by
In general biology, core biological organization dictates that structure-function relationships govern cellular processes. Therefore ortholog clustering and conserved gene order. is correct as it integrates fundamental life science principles, supported by mechanistic studies and conserved across related systems.
Ref: Campbell et al., Biology, 11th Edition, Chapter 2, Chemical Basis of Life, discusses fundamental biological principles, molecular organization, cellular structure and metabolic processes providing broad foundation for life sciences understanding and integration.