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#virus genomes

2 public questions tagged with this topic.

Gene and Genome

Ambisense genome contains:

Ambisense coding strategy observed in arenaviruses, phleboviruses and tospoviruses combines positive and negative polarity within same RNA segment. Each segment contains two open reading frames in opposite orientation separated by intergenic hairpin acting as transcription termination signal. One gene is expressed from genomic strand as negative-sense, the second from antigenomic complementary strand as positive-sense after replication. This arrangement allows regulation of gene expression timing and genome compactness. It differs from fully negative or positive genomes by encoding proteins fr

Ref: Nguyen M, Haenni AL, Virology 2003: Ambisense Genome Contains Both Sense in Same RNA

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Gene and Genome

Segmented genome is typical of:

Segmented genomes divide viral nucleic acid into multiple fragments packaged within single particle or distinct particles requiring co-infection for productive replication. Orthomyxoviridae including influenza A virus carry eight negative-sense RNA segments encoding polymerase subunits, hemagglutinin, neuraminidase, nucleoprotein and nonstructural proteins, facilitating genetic reassortment during co-infection leading to antigenic shift responsible for pandemics. Reoviruses have 10-12 dsRNA segments, bunyaviruses three segments. Segmentation contrasts monopartite genomes like poliovirus contai

Ref: Palese P, Shaw ML, Orthomyxoviridae, Fields Virology: Segmented Genome Typical of Influenza Virus

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