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#transmembrane protein

2 public questions tagged with this topic.

Plasma Membrane Proteins

Which transmembrane protein is a seven-pass receptor involved in signal transduction?

Seven-transmembrane receptor family also termed heptahelical receptors or G protein-coupled receptors comprises largest receptor superfamily in human genome over eight hundred members including rhodopsin-like class A, secretin class B and glutamate class C. Architecture consists of extracellular N-terminal domain ligand binding, seven hydrophobic alpha-helices TM1 through TM7 each nineteen to twenty seven residues traversing membrane with three extracellular loops ECL1-3 and three intracellular loops ICL1-3 and intracellular helix eight parallel to membrane interacting with heterotrimeric G pr

Ref: Rosenbaum et al., The Structure and Function of GPCRs, Nature 2009.

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Plasma Membrane Proteins

Which of the following interactions primarily stabilizes transmembrane proteins within the lipid bilayer?

Stabilization of transmembrane segments inside bilayer originates from hydrophobic effect plus van der Waals packing. Sec61 translocon provides aqueous pore laterally gated allowing nascent hydrophobic sequence to partition directly into lipid phase assessed by apparent free energy scale of Hessa and von Heijne measuring contribution per residue leucine minus zero point five six kilocalories, arginine positive two point five kilocalories. Burying non-polar side chains of leucine isoleucine valine phenylalanine methionine avoids forcing water to form ordered clathrate cages around them, releasi

Ref: White and von Heijne, How Translocons Select Transmembrane Helices, Annu Rev Biophys 2008.

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