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#spectrin

3 public questions tagged with this topic.

Plasma Membrane Proteins

Which protein is responsible for maintaining the biconcave shape of RBCs?

Maintenance of biconcave disc shape maximizing surface to volume ratio for deformability and gas exchange depends on membrane skeleton elasticity and organization. Spectrin consists of alpha two hundred eighty kilodalton and beta two hundred forty six kilodalton subunits each containing twenty triple-helical spectrin repeats of one hundred six residues forming elongated flexible anti-parallel heterodimer one hundred nanometers long, two heterodimers associate head to head via helical bundle forming tetramer about two hundred nanometers acting as entropic spring with persistence length about te

Ref: Lux and Palek, Erythrocyte Membrane Skeleton and Spectrin Elasticity, Blood Cells.

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Plasma Membrane Proteins

Which of the following best describes the function of Ankyrin?

Erythrocyte mechanical stability depends on vertical linkages mediated by ankyrin-R isoform one hundred ninety kilodaltons to two hundred ten kilodaltons comprising three distinct domains enabling integration. N-terminal membrane binding domain contains twenty four tandem ankyrin repeats each thirty three residues forming elongated superhelical solenoid that creates concave binding surface recognizing cytoplasmic loop of Band 3 anion exchanger between residues one hundred seventy five to one hundred eighty five with nanomolar affinity, also binding Na K ATPase alpha subunit, voltage gated sodi

Ref: Mohandas and Peters, Erythrocyte Cytoskeleton and Ankyrin Function, Annu Rev Med.

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Plasma Membrane Proteins

Which of the following is a structural protein providing support to the RBC membrane?

Erythrocyte membrane mechanical resilience originates from spectrin ankyrin network linkage. Ankyrin-1 large adaptor of approximately two hundred six kilodaltons comprises three domains: N-terminal membrane binding domain of twenty four ankyrin repeats each thirty three residues forming elongated solenoid that binds high affinity site on Band 3 cytoplasmic domain residues one seventy five to one eighty five and other integral proteins sodium-potassium ATPase, sodium channel Nav1.5, cell adhesion molecule L1; central spectrin binding domain of about one hundred residues binding beta spectrin re

Ref: Bennett and Healy, Membrane Protein Complexes and Ankyrin Function, Annu Rev Cell Dev Biol.

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