Which of the following organelles is involved in detoxification?
Detoxification of endogenous metabolites and exogenous xenobiotics requires oxidative handling and compartmentalization to protect cellular components. Peroxisomes, single membrane organelles containing enzymes imported via peroxisomal targeting signals PTS1 C-terminal SKL tripeptide and PTS2 N-terminal recognized by shuttling receptors PEX5 and PEX7, house acyl-CoA oxidases that beta-oxidize very-long-chain fatty acids C22 and above and branched-chain fatty acids like phytanic acid generating acetyl-CoA for mitochondria plus hydrogen peroxide H2O2 as byproduct. Catalase, core component with h
Ref: Alberts et al., Molecular Biology of the Cell, 7th ed., Chapter 12: Peroxisomes and Detoxification.
