Which transporter is primarily responsible for glucose uptake in the small intestine?
Dietary carbohydrate absorption predominantly occurs in duodenum and jejunum where luminal concentrations fluctuate from millimolar after meal to micromolar between meals, requiring active accumulation. Enterocytes polarized with brush border apical membrane expressing SGLT1 coded by SLC5A1 high affinity sodium glucose cotransporter belonging to sodium substrate symporter family LeuT fold with 14 transmembrane helices, sodium binding sites Na1 Na2 coordinating carbonyls and glucose vestibule lined by aromatic residues conferring D-glucose galactose specificity. Stoichiometry two sodium per one
Ref: Wright et al., Physiol Rev, SGLT1 Sodium Glucose Cotransporter Intestinal Glucose Absorption Mechanism.
