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#second messengers

3 public questions tagged with this topic.

Cell Signaling ELR Pathways - I

PLCγ activation produces which second messengers?

IP3 and DAG, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Signaling GPCR Pathways - I

Which is NOT a second messenger?

Second messengers are small, diffusible intracellular molecules generated in response to receptor activation. Classic examples include cyclic AMP, cyclic GMP, inositol 1,4,5-trisphosphate, diacylglycerol and Ca2+. Hormones such as insulin act as primary messengers and are not themselves second messengers. The rapid rise and fall of second-messenger concentrations allow precise temporal control of downstream signaling pathways.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Signaling Fundamental Principles

Second messengers include

Second messengers are small, diffusible intracellular molecules generated in response to receptor activation. Classic examples include cyclic AMP, cyclic GMP, inositol 1,4,5-trisphosphate, diacylglycerol and Ca2+. Hormones such as insulin act as primary messengers and are not themselves second messengers. The rapid rise and fall of second-messenger concentrations allow precise temporal control of downstream signaling pathways.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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