What type of targeting sequence do peroxisomal matrix proteins contain?
Peroxisomes single-membrane oxidative organelles ubiquitous eukaryotes performing fatty acid alpha beta-oxidation very long chain branched chain detoxifying hydrogen peroxide catalase plasmalogen ether lipid synthesis. Matrix content exceeding 50 enzymes imported post-translationally cytosol free ribosomes. Majority around 90 percent carry peroxisomal targeting signal type 1 PTS1 extreme C-terminus tripeptide (S/A/C)-(K/R/H)-(L/M) canonical most efficient Ser-Lys-Leu derived firefly luciferase discovery. Additional upstream residues modulate affinity receptor. PTS1 recognized tetratricopeptide
Ref: Lodish et al., MCB: PTS1 SKL tripeptide targets matrix proteins to peroxisomes.
