Which of the following best describes the pathway of secretory proteins?
Classical secretory pathway described by George Palade using pulse-chase autoradiography follows polarized itinerary from synthesis to release. Proteins destined for secretion start on rough ER where N-terminal signal peptide directs co-translational insertion via Sec61 channel and cleavage by signal peptidase. Core N-glycosylation, chaperone assisted folding and disulfide formation occur there before concentration at ER exit sites organized by Sec16 and COPII coat assembly controlled by Sar1 GTPase. Vesicles form ER-Golgi intermediate compartment and fuse into cis-Golgi cisterna. Cargo then t
Ref: Lodish et al., Molecular Cell Biology, 9th ed., Chapter 14: Secretory Pathway ER to Golgi to PM.
