GGQ motif is associated with
The Gly-Gly-Gln motif represents the catalytic signature of class I release factors positioned at the tip of the universally conserved GGQ loop that inserts into peptidyl transferase center. In the large subunit, the glutamine side chain is N5-methylated by methyltransferases, allowing precise positioning of a water molecule for nucleophilic attack on the ester bond linking nascent peptide to P-site tRNA, thereby liberating the completed chain during termination. Mutagenesis of GGQ abolishes peptide release while retaining stop codon recognition, demonstrating separation of decoding and cataly
Ref: Lodish Molecular Cell Biology Fig 4-35; NCBI Structure 1R5N - GGQ motif catalyzes peptidyl-tRNA hydrolysis in termination
