The nuclear pore complex (NPC) primarily consists of:
Nuclear pore complexes are massive one hundred ten to one hundred twenty megadalton assemblies spanning two lipid bilayers with eightfold rotational symmetry, comprised of about thirty distinct proteins called nucleoporins organized into scaffold and barrier layers. Y-complex Nup107-Nup160 forms outer rings, Nup93-Nup205 inner ring, and intrinsically disordered FG-repeat nucleoporins such as Nup62 complex, Nup98, Nup214 line central channel forming selective hydrogel that blocks nonspecific diffusion above forty kDa while allowing receptor-mediated transport. Importin beta family receptors bin
Ref: Rout & Aitchison Annu Rev Biochem; NPC 30 nucleoporins FG barrier selective transport.
