Which structure is involved in lipid trafficking between organelles?
Efficient movement lipids between organelles employs both vesicular carriers clathrin COPII COPI and non vesicular lipid transfer membrane contact sites where domain organization guides sorting specificity and lipid gradients. Vesicular pathway buds donor via coat proteins packaging lipids proteins, while lipid driven sorting trans Golgi network concentrates sphingolipids cholesterol GPI anchored proteins into rafts destined apical plasma membrane demonstrated sorting influenza hemagglutinin placental alkaline phosphatase independent cytosolic sorting signals tyrosine dileucine. Flotillin cave
Ref: Simons & Sampaio, Cold Spring Harb Perspect 2011, Lipid raft sorting trafficking platforms and MCS.
