Cry I toxins are effective mainly against:
Phylogenetic analysis of Cry toxin specificity demonstrates that Cry1 subclass efficiently kills lepidopterans due to complementarity of domain II loops to cadherin repeats conserved in caterpillar midguts. Cry1Aa, Cry1Ab, Cry1Ac share receptor binding epitopes recognizing glycosylated residues of cadherin CR12 and interaction with ABCC2 transporter facilitating membrane insertion. Larvae of Helicoverpa, Heliothis, Ostrinia, Pectinophora, and Plutella possess this receptor, making them highly susceptible even at low Cry concentrations expressed in transgenic leaf tissue. Activity against Coleo
Ref: Bravo Ann Rev Entomol 2007 Cry1 lepidopteran; Tabashnik 1994 field; NCBI NBK24601; Crickmore 1998 specificity; PubMed 15012339.
