Which nuclear domain is associated with transcriptionally inactive chromatin?
Mammalian nucleus partitions chromatin into active and inactive states with distinct cytology and epigenetic marks. Euchromatin appears lightly stained, decondensed, nuclease hypersensitive and enriched in histone acetylation, H3K4 trimethylation, H3K36 methylation associated with ongoing transcription and replication early S phase, located interiorly. Heterochromatin appears electron dense, concentrates at periphery adjacent to nuclear lamina, around nucleolus and at centromeres, enriched in H3K9 trimethylation, H4K20 trimethylation, HP1 binding and DNA methylation repressing transcription by
Ref: Grewal Annu Rev Genet; heterochromatin H3K9me3 HP1 transcriptionally silent peripheral, euchromatin active.
