Which statement is correct about farnesylation?
Farnesylation is post-translational prenylation catalyzed by heterodimeric farnesyltransferase FTase using farnesyl pyrophosphate derived from mevalonate cholesterol biosynthesis pathway as donor. Modification occurs at CAAX motif at extreme C-terminus where C is cysteine, A aliphatic residues, X typically methionine, serine or glutamine directing farnesyl addition versus leucine directing geranylgeranyl addition. Reaction forms thioether bond between cysteine sulfur and C1 of isoprenoid. Farnesyl group is linear 15-carbon isoprene polymer comprising three isoprene units with 3 double bonds pr
Ref: Zhang & Casey, Annu Rev Biochem 1996, Farnesylation; Wang & Casey 2016.
