Which of the following statements about membrane proteins is FALSE?
Fluid mosaic model postulates membrane proteins diffuse laterally, associate with cytoskeleton, function as enzymes receptors carriers and structural anchors. Transverse movement of proteins between leaflets termed flip-flop faces enormous energetic barrier because large hydrophilic extramembranous domains containing charged residues lysine arginine aspartate glutamate would need dehydration and passage through hydrocarbon core twenty to thirty angstroms low dielectric constant incurring free energy tens kilocalories plus disruption of established orientation determined during biogenesis at Se
Ref: Alberts et al., Molecular Biology of the Cell, 6th ed., Chapter 10, Membrane Protein Topology and Asymmetry.
