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Blank needs 'ambitious'; context demands this word grammatically.
Ref: British Council grammar guide explains adjective fond always followed by preposition of standard collocation pattern English usage.
Specification and determination both indicate commitment but differ fundamentally in stability and reversibility. Specification is labile; tissue cultured neutrally follows preferred pathway, yet when grafted into foreign embryonic region receiving different BMP, Wnt or FGF signals, it can alter fate to match host. Determination involves molecular lockdown through cis-regulatory modifications, DNA methylation, Polycomb repression of alternative programs and autoregulatory transcription factor circuits exemplified by MyoD autoactivation in muscle. Determined cells maintain donor identity after
Ref: Gilbert, Developmental Biology, 12th ed., Chapter 5: Determination as Irreversible Commitment.
Determination is conceptualized as the stable, essentially irreversible commitment of a cell to a particular differentiation pathway, following an earlier labile specification phase. During specification, fate preference is established but can still be redirected by changing embryonic environment or transplantation. Determination involves profound molecular stabilization including positive feedback loops among selector genes like MyoD in myoblasts, extensive chromatin remodeling, DNA methylation and Polycomb-mediated repression of alternative programs. Once determined, cells execute differenti
Ref: Gilbert, Developmental Biology, 12th ed., Chapter 5: Determination and Specification Concepts.
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