Which type of myosin is primarily involved in non-muscle cell contractility?
Non muscle contractility underpins stress fiber maintenance, adhesion maturation, morphogenesis and wound closure, distinct from skeletal muscle sarcomeres employing troponin regulation. Myosin II family in non muscle cells includes isoforms IIA, IIB and IIC sharing hexameric composition two heavy chains plus essential and regulatory light chains, forming short bipolar filaments that transiently associate with actin rather than stable thick filaments. Activation occurs via phosphorylation of 20 kilodalton regulatory light chain RLC at Ser19 by calcium calmodulin dependent MLCK and Rho associat
Ref: Lodish et al., Molecular Cell Biology, 9th ed., Chapter 18: Nonmuscle Myosin II in Contractility.
