Compensatory regeneration differs because it:
Compensatory regeneration represents distinct strategy where organ mass restored without blastema formation and without loss of functional differentiation. Hepatocytes continue synthesizing plasma proteins, metabolizing, while dividing after partial hepatectomy driven by IL-6, TNF-alpha, HGF signaling. No dedifferentiation to progenitor occurs, lineage remains restricted, organ architecture restored by hypertrophy and hyperplasia of functional cells. This contrasts epimorphosis requiring dedifferentiation and morphallaxis involving repatterning with transdifferentiation. Maintaining differenti
Ref: Gilbert, Developmental Biology, 12th ed., Chapter 21: Compensatory regeneration maintaining differentiated function.
