Which ATP pump is involved in generating acidic pH inside organelles like lysosomes?
Generating acidic interior in endocytic compartments essential for cargo sorting, iron release from transferrin, ligand receptor dissociation, viral entry and lysosomal hydrolysis demands active proton translocation against roughly two pH units. Main machinery responsible is vacuolar proton ATPase V-type, large composite enzyme about 900 kilodaltons composed of peripheral V1 complex A3B3CDE3FG3H where A3B3 hexamer contains catalytic ATP hydrolysis sites at alternating interfaces, and integral membrane Vo complex including a subunit with two half channels, c-ring of nine to ten copies c, c doub
Ref: Forgac, V-ATPase Review, Acidification of Lysosomes and Endosomes by V-Class Proton Pump.
