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#cell migration

7 public questions tagged with this topic.

Morphogen Induction-l

Which of the following morphogens is involved in neural crest migration?

Neural crest specification and migration rely on coordinated Wnt and BMP signaling at neural plate border. Canonical Wnt6 from non-neural ectoderm plus intermediate BMP activate border factors Snail2, FoxD3, Sox9 defining premigratory crest. Wnt signaling activates beta-catenin transcription of Slug promoting epithelial-mesenchymal transition, delamination and acquisition of migratory machinery including integrins and metalloproteinases. Post-delamination, Wnt guides directional migration and proliferation of crest derivatives. BMP4 contributes to delamination but primary motility driver is Wn

Ref: Mayor and Theveneau, Development 2013, Wnt Signaling in Neural Crest Migration.

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Chick development-ll

Migration through the primitive streak is directly regulated by:

Migration of epiblast through streak is active EMT driven by FGF signaling. FGF8 secreted by streak cells activates FGFR1 on neighboring epiblast via MAPK and PI3K pathways upregulating Snail2 repressing E-cadherin, permitting ingression. After EMT FGF acts as chemorepellent guiding mesoderm laterally. Inhibition with SU5402 or dominant-negative FGFR blocks ingression causing epiblast accumulation. Noggin, chordin and goosecoid dorsalize after ingression but do not regulate migration machinery itself. Therefore migration through primitive streak directly regulated by FGF8 acting as both EMT in

Ref: Stern, FGF8 regulation of ingression and migration through chick primitive streak, Development Journal.

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Dictyostelium

Stage following migration:

After phototactic migration, slug selects drier spot where ammonia dissipates, enabling culmination phase where anterior prestalk cells undergo programmed vacuolization, synthesize cellulose walls, and crawl down through prespore mass in reverse fountain movement forming stalk tube. Prespore cells ascend and encapsulate into spores atop stalk. This dramatic morphogenetic transition occurs without cell division, relying solely on sorting and terminal differentiation. Vegetative growth precedes aggregation, aggregation precedes migration; spore dispersal occurs only after culmination completes.

Ref: Gilbert, Developmental Biology, 12th ed., Chapter 22: Culmination - reverse fountain movement and stalk tube formation.

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Cancer

EMT promotes metastasis mainly by

Enhancing migratory and invasive properties, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cancer

Epithelial–mesenchymal transition (EMT) is associated with

Increased invasion and metastasis, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Communication and ECM

ECM degradation during cell migration is mediated by

Matrix metalloproteinases, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Signaling ELR Pathways - I

FAK autophosphorylation creates docking site for

Src family kinases, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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