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#blood vessels

31 public questions tagged with this topic.

Which type of blood vessel has the thickest walls?

**Arteries** have thick walls to withstand high blood pressure as they carry blood away from the heart. This follows from NCERT principle where the relation explains the outcome clearly for students in simple steps.

Ref: NCERT Biology Textbook for Class XI and XII (Zoology section), Chapter: Biology - Zoology portion covering relevant system and function.

Target cells in cardiovascular gene therapy include:

Endothelial cell central therapeutic target cardiovascular gene therapy because monolayer regulates vascular homeostasis via eNOS converting L-arginine to nitric oxide stimulating soluble guanylate cyclase raising cGMP relaxing smooth muscle, prostacyclin via COX2 inhibiting platelet aggregation, barrier integrity VE-cadherin junctions, leukocyte adhesion E-selectin VCAM1. Dysfunction oxidative stress uncoupling eNOS drives atherosclerosis hypertension ischemia. Ischemic peripheral artery disease refractory angina benefit proangiogenic factors VEGF-A165, FGF4, HGF, HIF1-alpha delivered AAV1 or

Ref: Circ Res Cardiovascular Gene Therapy Endothelial Targets 2022; NHLBI Vascular Gene Therapy Overview; Lodish Vascular Biology Endothelial Function Chap 22.