The bacterial reproduction process of binary fission differs from mitosis in that:
Binary fission represents prokaryotic division program fundamentally distinct from eukaryotic mitosis in mechanism and regulation. Initiation begins with replication of single circular chromosome from unique origin oriC proceeding bidirectionally via replisomes containing DNA polymerase III. Segregation of origins is mediated by ParABS partitioning system and SMC condensin complexes moving DNA toward opposite poles as cell elongates via MreB-guided peptidoglycan insertion. Division site selection uses precise regulatory systems: oscillating MinCDE proteins concentrate MinC inhibitor at poles p
Ref: Madigan et al., Brock Biology of Microorganisms, 16th ed., Chapter 4: Binary Fission and Absence of Spindle Apparatus.
