Which molecule acts as an electron donor in bacterial oxidative stress response?
Redox homeostasis during oxidative stress requires continuous electron flow from reduced pyridine nucleotide NADPH generated by pentose phosphate pathway to thiol antioxidant enzymes. Thioredoxin is small 12 kDa dithiol protein with highly conserved WCGPC active motif forming reversible intramolecular disulfide acting as mobile electron shuttle. Reduced thioredoxin provides low-potential electrons directly to peroxiredoxins such as AhpC and Tpx that reduce hydrogen peroxide and organic peroxides to water and alcohols, to methionine sulfoxide reductases MsrA and MsrB that repair oxidized methio
Ref: Alberts et al., Molecular Biology of the Cell, 7th ed., Chapter 7: Thioredoxin as Electron Donor in Oxidative Defense.
