How does Aurora B kinase correct incorrect kinetochore attachments?
Early prometaphase generates many attachment errors because kinetochores initially capture microtubules stochastically. Syntelic where both sisters attach same pole, monotelic where only one sister attached, and merotelic where one kinetochore attached to both poles often arise. These erroneous configurations lack balanced tension between sister centromeres. Aurora B kinase, as catalytic component of chromosomal passenger complex concentrated at inner centromere between sisters, senses low tension via proximity gradient. Active when kinetochores are close, Aurora B phosphorylates N-terminal ta
Ref: Lampson & Cheeseman, Aurora B-Dependent Error Correction of Kinetochore Attachments, Nat Rev Mol Cell Biol 2011; Nature Communications, CPC.
