Which of the following best describes the function of Ankyrin?
Erythrocyte mechanical stability depends on vertical linkages mediated by ankyrin-R isoform one hundred ninety kilodaltons to two hundred ten kilodaltons comprising three distinct domains enabling integration. N-terminal membrane binding domain contains twenty four tandem ankyrin repeats each thirty three residues forming elongated superhelical solenoid that creates concave binding surface recognizing cytoplasmic loop of Band 3 anion exchanger between residues one hundred seventy five to one hundred eighty five with nanomolar affinity, also binding Na K ATPase alpha subunit, voltage gated sodi
Ref: Mohandas and Peters, Erythrocyte Cytoskeleton and Ankyrin Function, Annu Rev Med.
