Practice question
Question
What are the Yamanaka factors used for iPSCs reprogramming?
Explanation
Shinya Yamanaka demonstrated somatic cells reprogram to pluripotent stem cells by overexpressing four transcription factors: Oct3/4, Sox2, Klf4 and c-Myc. These induce endogenous pluripotency network, silencing differentiation genes, enabling generation of induced pluripotent stem cells for regenerative medicine and disease modeling.
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