Practice question
Question
Ligand for TLR3 receptor is:
Explanation
TLR3 is endosomal pattern recognition receptor recognizing double-stranded RNA produced during viral replication. Binding dsRNA recruits TRIF adaptor, activating IRF3 and NF-kB pathways leading to type I interferon production. LPS binds TLR4, lipopeptides TLR2, flagellin TLR5, not TLR3.
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