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#Hippo signaling

4 public questions tagged with this topic.

Fertilization in mammals-ll

Hippo signaling promotes differentiation into:

First lineage decision in blastocyst is regulated by differential Hippo signaling based on cell position and polarity. Inner apolar cells activate Lats1/2 kinases, phosphorylate YAP leading to cytoplasmic sequestration and degradation, preventing TEAD activity, thus permitting Oct4 driven inner cell mass specification. Outer polarized cells possess apical domains that inhibit Lats, permitting nuclear YAP accumulation and TEAD-dependent Cdx2 expression specifying trophectoderm. Genetic ablation converting Hippo ON to OFF shifts inner cells toward extra trophectoderm, confirming Hippo promotes ICM fate, suppresses TE program during early embryogenesis and lineage segregation events.

Ref: Nishioka et al., Dev Cell 2009: Hippo signaling regulates YAP localization and ICM vs trophectoderm fate decision.

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Cell Signaling Other Signaling Pathways

Loss of Hippo signaling commonly leads to

tumorigenesis, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Signaling Other Signaling Pathways

High cell density activates Hippo signaling via

E-cadherin mediated cell contact, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Signaling Other Signaling Pathways

Active Hippo signaling results in

YAP/TAZ degradation, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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