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#collagen synthesis

6 public questions tagged with this topic.

Proteolytic removal of propeptides from procollagen occurs in

Extracellular space, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

Hydroxylation of proline and lysine residues occurs in

Endoplasmic reticulum, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

Vitamin C deficiency affects collagen by impairing

Hydroxylation of Pro and Lys, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

Which of the following diseases is caused by defective collagen synthesis due to Vitamin C deficiency?

Scurvy is the correct answer because it serves as the specific precursor, synthetic product, or metabolic intermediate described in this question. Biosynthetic pathways in Protein follow precise enzymatic steps where specific substrates are converted to products through regulated metabolic reactions. Scurvy occupies a key position in this metabolic pathway due to its chemical structure and reactivity. The other options (Osteogenesis imperfecta, Ehlers-Danlos syndrome, and Marfan syndrome) are involved in different biosynthetic routes, serve as precursors for different end products, or participate in unrelated metabolic conversions.

Ref: Lehninger Principles of Biochemistry, Nelson & Cox, 8th Ed., Ch. 4

Which vitamin is essential for the hydroxylation of proline and lysine in collagen synthesis?

Vitamin C is the correct answer because it serves as the specific precursor, synthetic product, or metabolic intermediate described in this question. Biosynthetic pathways in Protein follow precise enzymatic steps where specific substrates are converted to products through regulated metabolic reactions. Vitamin C occupies a key position in this metabolic pathway due to its chemical structure and reactivity. The other options (Vitamin A, Vitamin D, and Vitamin K) are involved in different biosynthetic routes, serve as precursors for different end products, or participate in unrelated metabolic conversions.

Ref: Lehninger Principles of Biochemistry, Nelson & Cox, 8th Ed., Ch. 4