Practice question

Permissive induction describes interaction where responder is already determined and inductor merely provides permissive environment allowing execution of intrinsic program. Mammary epithelium predetermined for milk protein synthesis requires laminin-rich basement membrane to activate prolactin signaling and STAT5. Without matrix genes remain silent but potential persists, demonstrating matrix dependence. This contrasts with instructive where new genes induced de novo. Matrix acts as scaffold enabling survival, polarity and transcription, reflecting supportive rather than instructive role during late differentiation and functional maturation stages.