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Practice question

MCQ

Question

The ATP-dependent pathway of protein degradation in eukaryotic cells is quite different, involving the protein ubiquitin. Ubiquitin is covalently linked to proteins determined for destruction via an ATP-dependent pathway involving three separate types of enzymes. Identify correct set of three separate types of enzymes.

Options

Choose one · Correct answer highlighted

Explanation

Ubiquitin is activated by E1 ubiquitin-activating enzyme using ATP forming thioester. It transfers to E2 conjugating enzyme, then E3 ligase provides substrate specificity, catalyzing isopeptide bond formation between ubiquitin C-terminus and lysine of target protein for proteasomal degradation.

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