Practice question
Question
In chronic kidney disease, hyperkalemia is often a concern due to impaired renal excretion. Which hormone’s decreased activity exacerbates this condition?
Explanation
Aldosterone via mineralocorticoid receptor increases Na+ reabsorption and K+ secretion in collecting duct principal cells. CKD reduces renal mass and impairs RAAS, lowering aldosterone responsiveness and K+ excretion. Hypoaldosteronism thus worsens hyperkalemia, especially with diabetes or ACE inhibitor use.
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