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Practice question

MCQ

Question

Given below are two statements : Statement I : In lyonization of X chromosome inactivation, all the genes of one X chromosome are switched off. Statement II : In most phenotypic males with a karyotype of 46, XX, the SRY is present and found on one of the X chromosomes. In the light of the above statements, choose the correct answer from the options :

Options

Choose one · Correct answer highlighted

Explanation

Lyonization inactivates most, not all, genes on one X; ~15% escape inactivation, retaining biallelic expression. In 46,XX testicular DSD, ~90% have SRY translocated to Xp during paternal meiosis, explaining male phenotype despite XX karyotype, making statement II true and I false.

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